1883549-35-6
1883549-35-6
Chemical Structure
Icerguastat Carbonate
Synonym(s): Sephin1 Carbonate; IFB-088 Carbonate
- CAS No.: 1883549-35-6
- Formula:C9H11ClN4O3
- Molecular Weight:258.66
IUPAC Name: (E)-2-(2-chlorobenzylidene)hydrazine-1-carboximidamide carbonate
InChIKey: LCQVFBONUDQAEH-NKPNRJPBSA-N
SMILES: ClC1=C(C=CC=C1)/C=N/NC(N)=N.OC(O)=O
Biological Activity: Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3].
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Icerguastat Carbonate | Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect. | |||||||||||||||||||||
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References
- [1]. Chen Y, et al. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019;142(2):344-361. [Content Brief]
- [2]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348(6231):239-242. [Content Brief]
- [3]. Thapa S, et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Mol Neurobiol. 2020;57(5):2206-2219. [Content Brief]
