1883711-97-4
1883711-97-4
Chemical Structure
AM-0902
- CAS No.: 1883711-97-4
- Formula:C17H15ClN6O2
- Molecular Weight:370.79
IUPAC Name: 1-((3-(4-chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1,7-dihydro-6H-purin-6-one
InChIKey: AWJBWNUUODWOKQ-UHFFFAOYSA-N
SMILES: O=C1N(CC2=NC(CCC3=CC=C(Cl)C=C3)=NO2)C=NC4=C1N(C)C=N4
Biological Activity: AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AM-0902 | 99.73% | AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively. | ||||||||||||||||||||
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AM-0902 (Standard) | AM-0902 (Standard) is the analytical standard of AM-0902 (HY-108329). This product is intended for research and analytical applications. AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively. | |||||||||||||||||||||
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HC-070 | 99.74% | HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. | ||||||||||||||||||||
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GR-175737 | GR 175737 is a partial histamine H3 receptor agonist, with an EC50 of 7.8 nM. GR 175737 can be used in the research of inflammatory diseases. | |||||||||||||||||||||
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VU0071063 | 99.58% | VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC50=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships. | ||||||||||||||||||||
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Ibezapolstat | 98.0% | Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI). | ||||||||||||||||||||
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TRPA1-IN-1 | TRPA1-IN-1 is a potent, selective, and orally bioavailable TRPA1 small molecule antagonist. | |||||||||||||||||||||
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BRD4-BD1-IN-2 | BRD4-BD1-IN-2 is a selective BRD4-BD1 inhibitor, with an IC50 of 2.51 µM (20-times greater than that of BD2). BRD4-BD1-IN-2 can be used in studies of cancer and cardiovascular diseases. | |||||||||||||||||||||
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DprE1-IN-5 | DprE1-IN-5 (Compound 10) is a DprE1 inhibitor. DprE1-IN-5 has anti-TB activity against Mtb H37Rv strain (MIC: 4 μM). DprE1-IN-5 also has antimycobacterial activity against drug-resistant strains. DprE1-IN-5 has high microsomal stability. | |||||||||||||||||||||
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Nedizantrep | 99.56% | GDC-6599 is an orally active TRPA1 inhibitor, with IC50 values of 5.3 nM in humans, 6.6 nM in rats, 9.3 nM in dogs, 7.2 nM in monkeys, and 15 nM in guinea pigs. GDC-6599 can be used in the research of neuropathic pain and respiratory diseases such as asthma and chronic cough. | ||||||||||||||||||||
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Anticancer agent 230 | 99.77% | Anticancer agent 230 (example 65) is a caseinolytic protease P (ClpP) activator with anticancer activity. Anticancer agent 230 is able to induce the degradation of mitochondrial proteins in SUM159 and MDA-MB-231 triple-negative breast cancer cells in a time-dependent manner. | ||||||||||||||||||||
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Dimabefylline | Dimabefylline is an antimicrobial compound. | |||||||||||||||||||||
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