1883721-73-0
1883721-73-0
Chemical Structure
SF-3-030
- CAS No.: 1883721-73-0
- Formula:C14H12O5S2
- Molecular Weight:324.37
IUPAC Name: 1,1-dioxido-2,3-dihydrothiophen-3-yl naphthalene-2-sulfonate
InChIKey: UPNQDWDUYZHCMB-UHFFFAOYSA-N
SMILES: O=S(=O)(OC1C=CS(=O)(=O)C1)C=2C=CC=3C=CC=CC3C2
Biological Activity: SF-3-030 is a potent, selective and non-ATP competitive ERK1/2 inhibitor. SF-3-030 selectively induces apoptosis in melanoma cells containing mutated BRaf and constitutively active ERK1/2 signalling. SF-3-030 mitigates multiple features of asthma in a murine model of asthma. SF-3-030 can be used for the research of asthma and melanomasup[1][2].
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SF-3-030 | SF-3-030 is a potent, selective and non-ATP competitive ERK1/2 inhibitor. SF-3-030 selectively induces apoptosis in melanoma cells containing mutated BRaf and constitutively active ERK1/2 signalling. SF-3-030 mitigates multiple features of asthma in a murine model of asthma. SF-3-030 can be used for the research of asthma and melanomasup. | |||||||||||||||||||||
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References
- [1]. Shah SD, et al. Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice. Am J Respir Cell Mol Biol. 2023 Jan;68(1):23-38. [Content Brief]
- [2]. Samadani R, et al. Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf. Biochem J. 2015;467(3):425-438. [Content Brief]
