1883730-99-1
1883730-99-1
Chemical Structure
LMP517
Synonym(s): NSC 781517
- CAS No.: 1883730-99-1
- Formula:C22H19FN2O5
- Molecular Weight:410.40
InChIKey: YFHMWOJCGJARKT-UHFFFAOYSA-N
SMILES: O=C1C2=CC3=C(C=C2C4=C1C5=C(C(N4CCCNCCO)=O)C=C(F)C=C5)OCO3
Biological Activity: LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LMP517 | 99.20% | LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer. | ||||||||||||||||||||
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NSC 727357 | NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma. | |||||||||||||||||||||
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KRN5 | 98.58% | KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis. | ||||||||||||||||||||
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Top-Tdp tri inhibitor C12 | Top-Tdp Tri Inhibitor C12 is a biochemical reagent. | |||||||||||||||||||||
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Indimitecan | 98.30% | Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. | ||||||||||||||||||||
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Indimitecan hydrochloride | Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities. | |||||||||||||||||||||
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Indotecan | 98.0% | Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis. | ||||||||||||||||||||
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Indotecan hydrochloride | 99.80% | Indotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan hydrochloride prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis. | ||||||||||||||||||||
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8-Keto-berberine | 8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine. | |||||||||||||||||||||
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LMP744 | 98.33% | LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. | ||||||||||||||||||||
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LMP744 hydrochloride | 99.08% | LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. | ||||||||||||||||||||
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References
- [1]. Marzi L, et al. The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2. Mol Cancer Ther. 2020 Aug;19(8):1589-1597. [Content Brief]
- [2]. Marzi L, et al. Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors. Mol Cancer Ther. 2018 Aug;17(8):1694-1704. [Content Brief]
