188428-79-7
Chemical Structure
DOTA-biotin
- CAS No.: 188428-79-7
- Formula:C36H54N8O11S
- Molecular Weight:806.93
InChIKey: XNDGMGWABJHCRC-DZBXECLCSA-N
SMILES: OC(CN(CCN(CCN(CCN(C1)CC(O)=O)CC(O)=O)CC(O)=O)C1CC(C=C2)=CC=C2NC(CN(C)C(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O)=O)=O
Biological Activity: DOTA-biotin is a bifunctional molecule formed by conjugating the chelator DOTA with biotin. The DOTA group of DOTA-biotin can form extremely stable complexes with a variety of radioactive metal nuclides, while the biotin group exhibits highly specific binding affinity for avidin or streptavidin. DOTA-biotin possesses rapid blood clearance activity and minimal systemic and non-target organ retention. DOTA-biotin can be used for cancer research[1][2][3][4].
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DOTA-biotin | DOTA-biotin is a bifunctional molecule formed by conjugating the chelator DOTA with biotin. The DOTA group of DOTA-biotin can form extremely stable complexes with a variety of radioactive metal nuclides, while the biotin group exhibits highly specific binding affinity for avidin or streptavidin. DOTA-biotin possesses rapid blood clearance activity and minimal systemic and non-target organ retention. DOTA-biotin can be used for cancer research. | |||||||||||||||||||||
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References
- [1]. Pratesi A, et al. Biotin derivatives carrying two chelating DOTA units. Synthesis, in vitro evaluation of biotinidases resistance, avidin binding, and radiolabeling tests. Journal of medicinal chemistry. 2010 Jan 14;53(1):432-40.
- [2]. Orcutt KD, et al. Biodistribution and clearance of small molecule hapten chelates for pretargeted radioimmunotherapy. Molecular imaging and biology. 2011 Apr;13(2):215-21. [Content Brief]
- [3]. Breitz HB, et al. Clinical optimization of pretargeted radioimmunotherapy with antibody-streptavidin conjugate and 90Y-DOTA-biotin. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2000 Jan;41(1):131-40.
- [4]. Schultz MK, et al. Synthesis of a DOTA--biotin conjugate for radionuclide chelation via Cu-free click chemistry. Organic letters. 2010 May 21;12(10):2398-401.
