188589-66-4
188589-66-4
Chemical Structure
Cl-4AS-1
- CAS No.: 188589-66-4
- Formula:C26H33ClN2O2
- Molecular Weight:441.01
IUPAC Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2-chlorophenyl)-1,4a,6a-trimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
InChIKey: CTVXDPDUOKQBKZ-GFNRTWGOSA-N
SMILES: O=C([C@H]1CC[C@]2([H])[C@]1(C)CC[C@]3([H])[C@@]4(C)C=CC(N(C)[C@]4([H])CC[C@]32[H])=O)NC5=CC=CC=C5Cl
Biological Activity: Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].
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Cl-4AS-1 | 99.64% | Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively). | ||||||||||||||||||||
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Cl-4AS-1 (Standard) | ≥98% | Cl-4AS-1 (Standard) is the analytical standard of Cl-4AS-1 (HY-103245). This product is intended for research and analytical applications. Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively). | ||||||||||||||||||||
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References
- [1]. Schmidt A, et al. Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J Biol Chem. 2009 Dec 25;284(52):36367-36376. [Content Brief]
- [2]. Tolman RL, et al. 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9. [Content Brief]
