1886065-39-9
Chemical Structure
DK 221
- CAS No.: 1886065-39-9
- Formula:C92H126N22O24S
- Molecular Weight:1956.18
InChIKey: JUSKLSSUBPZSQD-XQPAILSISA-N
SMILES: CN([C@H](C(N[C@H](C(NCC(N)=O)=O)CSCC(N[C@H]1CC2=CC=C(O)C=C2)=O)=O)CCCCN)C([C@@H](N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC([C@@H](NC([C@@H]4CCCN4C([C@@H](NC([C@@H](N(C1=O)C)C)=O)CC(N)=O)=O)=O)CC5=CNC=N5)=O)CCC(O)=O)=O)=O)CC6=CNC7=CC=CC=C76)=O)CO)=O)CC(C8=CC=CC=C89)=CN9CC(O)=O)=O)CCCC)=O)C)CCCC)=O
Biological Activity: DK 221 is a PD-L1 blocker with an IC50 of 24.5 nM for inhibiting the binding of PD-L1 to PD-1. DK 221 reduces the uptake of [18F]DK222 in PD-L1-positive tumor cells and mouse xenografts. DK 221 is applicable to research related to triple-negative breast cancer and melanoma[1].
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DK 221 | DK 221 is a PD-L1 blocker with an IC50 of 24.5 nM for inhibiting the binding of PD-L1 to PD-1. DK 221 reduces the uptake of [18F]DK222 in PD-L1-positive tumor cells and mouse xenografts. DK 221 is applicable to research related to triple-negative breast cancer and melanoma. | |||||||||||||||||||||
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