1887193-58-9
1887193-58-9
Chemical Structure
EPZ032597
- CAS No.: 1887193-58-9
- Formula:C20H23N7O
- Molecular Weight:377.44
InChIKey: SGVKMHGESLELKH-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2CC2)N=N1)NC3CN(C3)CC4=CN(CC5=CC=CC=C5)N=C4
Biological Activity: EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC50 value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma[1][2].
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EPZ032597 | EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC50 value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Alshammari E, et al. Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer. World J Gastroenterol. 2022 Aug 7;28(29):3753-3766. [Content Brief]
- [2]. Thomenius MJ, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018 Jun 1;13(6):e0197372. [Content Brief]
