1888305-17-6
1888305-17-6
Chemical Structure
ERK5-IN-4
- CAS No.: 1888305-17-6
- Formula:C16H11Cl2FN4O2
- Molecular Weight:381.19
IUPAC Name: 4-(3,6-dichloro-2-fluorobenzoyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrole-2-carboxamide
InChIKey: LIEUQFMVFKJKHX-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C(C2=C(Cl)C=CC(Cl)=C2F)=O)=CN1)NC3=CN(C)N=C3
Biological Activity: ERK5-IN-4 (compound 34b) is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). ERK5-IN-4 inhibits ERK5 (full-length) and truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with an IC50 of 77 nM and 300 nM, respectively[1].
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ERK5-IN-4 | ERK5-IN-4 (compound 34b) is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). ERK5-IN-4 inhibits ERK5 (full-length) and truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with an IC50 of 77 nM and 300 nM, respectively. | |||||||||||||||||||||
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