1888305-96-1
1888305-96-1
Chemical Structure
ERK5-IN-2
- CAS No.: 1888305-96-1
- Formula:C17H11BrFN3O2
- Molecular Weight:388.19
IUPAC Name: 4-(2-bromo-6-fluorobenzoyl)-N-(pyridin-3-yl)-1H-pyrrole-2-carboxamide
InChIKey: ATKCERYALDNMPL-UHFFFAOYSA-N
SMILES: FC1=CC=CC(Br)=C1C(C2=CNC(C(NC3=CC=CN=C3)=O)=C2)=O
Biological Activity: ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ERK5-IN-2 | 98.45% | ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis. | ||||||||||||||||||||
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