188859-65-6
![[Leu144,Arg147]-PLP (139-151) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p10456.gif "[Leu144,Arg147]-PLP (139-151) Chemical Structure")
Chemical Structure
[Leu144,Arg147]-PLP (139-151)
- CAS No.: 188859-65-6
- Formula:C67H110N20O17
- Molecular Weight:1467.71
InChIKey: YACBHKZFFYRFQI-RZGVDQIZSA-N
SMILES: O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)N
Biological Activity: [Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1].
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[Leu144,Arg147]-PLP (139-151) | [Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE). | |||||||||||||||||||||
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