189302-40-7
189302-40-7
Chemical Structure
nor-NOHA
Synonym(s): Nω-Hydroxy-nor-L-arginine
- CAS No.: 189302-40-7
- Formula:C5H12N4O3
- Molecular Weight:176.17
IUPAC Name: (S)-2-amino-4-(3-hydroxyguanidino)butanoic acid
InChIKey: KOBHCUDVWOTEKO-VKHMYHEASA-N
SMILES: O=C(O)[C@@H](N)CCNC(NO)=N
Biological Activity: nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism[1][2].
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nor-NOHA | nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism. | |||||||||||||||||||||
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References
- [1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254. [Content Brief]
- [2]. Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85(1):147-54. [Content Brief]
