1894207-45-4
1894207-45-4
Chemical Structure
Tisolagiline monomethylsulfate
Synonym(s): KDS2010 monomethylsulfate
- CAS No.: 1894207-45-4
- Formula:C18H21F3N2O4S
- Molecular Weight:418.43
IUPAC Name: (S)-2-(((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)amino)propanamide methanesulfonate
InChIKey: AXIUZWFYRNNIFL-MERQFXBCSA-N
SMILES: C[C@H](NCC1=CC=C(C2=CC=C(C(F)(F)F)C=C2)C=C1)C(N)=O.CS(=O)(O)=O
Biological Activity: Tisolagiline methylsulfate (KDS2010) is the selective, reversible and orally active inhibitor for MAO-B with an IC50 of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tisolagiline monomethylsulfate | 99.83% | Tisolagiline methylsulfate (KDS2010) is the selective, reversible and orally active inhibitor for MAO-B with an IC50 of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities. | ||||||||||||||||||||
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References
- [1]. Nam MH, et al. KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson's Disease. Neurotherapeutics. 2021 Jul;18(3):1729-1747. [Content Brief]
- [2]. Diep YN, et al., Astrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloid. Biomater Res. 2023 Jul 19;27(1):71 [Content Brief]
