1895083-75-6
1895083-75-6
Chemical Structure
Omburtamab
Synonym(s): Mab 8H9
- CAS No.: 1895083-75-6
- Formula:N/A
- Molecular Weight:(144.98 kDa)
SMILES: [Omburtamab]
Biological Activity: Omburtamab (Mab 8H9) is a mouse monoclonal immunoglobulin G1 (IgG1) antibody targeting B7-H3. Omburtamab specifically binds to the glycoprotein antigen B7-H3, which is widely expressed on the surface of tumor cells. As a targeting carrier for recombinant toxins, it delivers PE38 to inhibit cellular protein synthesis and induce cytotoxicity in antigen-expressing cancer cells. Omburtamab can be used in research related to glioma, breast cancer, osteosarcoma and neuroblastoma[1][2][3][4].
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Omburtamab | 99.16% | Omburtamab (Mab 8H9) is a mouse monoclonal immunoglobulin G1 (IgG1) antibody targeting B7-H3. Omburtamab specifically binds to the glycoprotein antigen B7-H3, which is widely expressed on the surface of tumor cells. As a targeting carrier for recombinant toxins, it delivers PE38 to inhibit cellular protein synthesis and induce cytotoxicity in antigen-expressing cancer cells. Omburtamab can be used in research related to glioma, breast cancer, osteosarcoma and neuroblastoma. | ||||||||||||||||||||
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References
- [1]. Onda M, et al. In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res. 2004 Feb 15;64(4):1419-24.
- [2]. Luther, et al. "Intraparenchymal and intratumoral interstitial infusion of anti-glioma monoclonal antibody 8H9." Neurosurgery 63.6 (2008): 1166-1174.
- [3]. Modak S, et al. Monoclonal antibody 8H9 targets a novel cell surface antigen expressed by a wide spectrum of human solid tumors. Cancer Res. 2001 May 15;61(10):4048-54. PMID: 11358824.
- [4]. Ahmed M, et al. Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3. J Biol Chem. 2015 Dec 11;290(50):30018-29.
