1895957-18-2
Chemical Structure
MMPP
- CAS No.: 1895957-18-2
- Formula:C17H18O3
- Molecular Weight:270.32
IUPAC Name: (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol
InChIKey: YXLMKJHTTWBHRD-HWKANZROSA-N
SMILES: OC1=CC=C(C=C1OC)/C=C/CC2=CC=C(C=C2)OC
Biological Activity: MMPP is an orally active inhibitor of STAT3 and VEGFR2, as well as an activator of PPARγ. MMPP blocks the VEGFR2/AKT/ERK/NF-κB signaling pathway to inhibit angiogenesis. MMPP inhibits ferroptosis and inflammation, and alleviates sepsis-induced myocardial injury. MMPP induces G1-phase cell cycle arrest and apoptosis, and inhibits the growth of non-small cell lung cancer (NSCLC) and solid tumors. MMPP promotes adipogenesis and glucose uptake. MMPP can be used in research related to NSCLC, type 2 diabetes and myocardial injury[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MMPP | 98.06% | MMPP is an orally active inhibitor of STAT3 and VEGFR2, as well as an activator of PPARγ. MMPP blocks the VEGFR2/AKT/ERK/NF-κB signaling pathway to inhibit angiogenesis. MMPP inhibits ferroptosis and inflammation, and alleviates sepsis-induced myocardial injury. MMPP induces G1-phase cell cycle arrest and apoptosis, and inhibits the growth of non-small cell lung cancer (NSCLC) and solid tumors. MMPP promotes adipogenesis and glucose uptake. MMPP can be used in research related to NSCLC, type 2 diabetes and myocardial injury. | ||||||||||||||||||||
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References
- [1]. Son DJ, et al. MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity Direct Binding to the STAT3 DNA-Binding Domain. Theranostics. 2017;7(18):4632-4642. [Content Brief]
- [2]. Kim NY, et al. MMPP is a novel VEGFR2 inhibitor that suppresses angiogenesis via VEGFR2/AKT/ERK/NF-κB pathway. BMB reports. 2024 May;57(5):244-249. [Content Brief]
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[3]. Kim NY, et al. MMPP promotes adipogenesis and glucose uptake via binding to the PPARγ ligand binding domain in 3T3-L1 MBX cells. Front Pharmacol. 2022 Oct 21;13:994584.
[Content Brief] - [4]. Liu C, et al. Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation. Bioactive materials. 2023 Jun;24:313-321. [Content Brief]
