190324-47-1
Chemical Structure
Pleurocidin
- CAS No.: 190324-47-1
- Formula:C129H192N36O29
- Molecular Weight:2711.13
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CC(C)C)=O)NC([C@H](CC2=CN=CN2)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](C(C)C)NC([C@H](CC3=CN=CN3)NC([C@H](CCCCN)NC(CNC([C@H](C(C)C)NC([C@H](CC4=CN=CN4)NC([C@H](C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC6=CC=CC=C6)NC([C@H](CO)NC(CNC([C@@H](NC(CN)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pleurocidin | 98.91% | Pleurocidin is an Antimicrobial peptide. Pleurocidin is derived from the skin mucosa or intestinal secretions of Pseudopleuronectes americanus. Pleurocidin inhibits the expression of key proteins in the MAPK and NF-κB inflammatory signaling pathways. Pleurocidin alters serum inflammatory and immune cytokine levels, regulates the down-regulation of tight junction proteins, and modulates the intestinal flora. Pleurocidin exerts antibacterial activity by inducing bacterial membrane damage, hydroxyl radical formation, and NADH depletion, and also produces a synergistic effect with Antibiotics. Pleurocidin alleviates DSS-induced ulcerative colitis. Pleurocidin can be used for research on ulcerative colitis, bacterial infections, and bacterial biofilm-related infections. | ||||||||||||||||||||
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References
- [1]. Nong K, et al. Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms. Int Immunopharmacol. 2024;130:111757. [Content Brief]
- [2]. Cole AM, et al. Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J Biol Chem. 1997;272(18):12008-12013. [Content Brief]
- [3]. Choi H, et al. Antimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity. Biochim Biophys Acta. 2012;1820(12):1831-1838. [Content Brief]
