1905412-80-7
Chemical Structure
AZD9362
- CAS No.: 1905412-80-7
- Formula:C24H27ClN8O2
- Molecular Weight:494.98
IUPAC Name: (R)-1-(4-(4-((5-chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)amino)-3,5-dimethyl-1H-pyrazol-1-yl)piperidin-1-yl)-2-hydroxypropan-1-one
InChIKey: PZKWAHCUWGHBLH-MRXNPFEDSA-N
SMILES: CC1=NN(C2CCN(C([C@H](O)C)=O)CC2)C(C)=C1NC3=NC=C(Cl)C(C4=C5C=CC=CN5N=C4)=N3
Biological Activity: AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer[1].
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AZD9362 | AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer. | |||||||||||||||||||||
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