1907724-92-8
Chemical Structure
Pezadeftide
Synonym(s): HXP124
- CAS No.: 1907724-92-8
- Formula:C234H372N70O66S8
- Molecular Weight:5478.41
SMILES: O=C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(O)=O)NC1=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H]6C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@H]8C(C)C)=O)NC6=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H]1CC9=CNC=N9)=O)=O)=O)NC8=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC%10=CNC=N%10)C(N[C@@H](CO)C(NCC(N[C@H]7CC%11=CC=C(C=C%11)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: Pezadeftide (HXP124) is a naturally derived plant defensin peptide molecule with antifungal activity. Pezadeftide binds to fungal cell wall chitin and β-glucan, enters fungal cells via endocytosis; induces mitochondrial membrane hyperpolarization, promotes ROS generation, further triggers vacuole fusion, alters plasma membrane permeability, and ultimately causes fungal cell death. Pezadeftide exhibits inhibitory effects against various skin and nail pathogenic fungi. Pezadeftide can be used in research related to fungal infections[1][2].
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Pezadeftide | Pezadeftide (HXP124) is a naturally derived plant defensin peptide molecule with antifungal activity. Pezadeftide binds to fungal cell wall chitin and β-glucan, enters fungal cells via endocytosis; induces mitochondrial membrane hyperpolarization, promotes ROS generation, further triggers vacuole fusion, alters plasma membrane permeability, and ultimately causes fungal cell death. Pezadeftide exhibits inhibitory effects against various skin and nail pathogenic fungi. Pezadeftide can be used in research related to fungal infections. | |||||||||||||||||||||
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References
- [1]. Van der Weerden NL, et al. Pezadeftide is a potent antifungal peptide with rapid fungicidial activity via a unique mechanism of action. J Am Acad Dermatol. 2022 Sep 1;87:Ab92.
- [2]. Parisi K, et al. Hyperpolarisation of Mitochondrial Membranes Is a Critical Component of the Antifungal Mechanism of the Plant Defensin, Ppdef1. Journal of fungi (Basel, Switzerland). 2024 Jan 07;10(1):54.
