1912408-92-4
Chemical Structure
Val-Ala-PAB-MMAE
- CAS No.: 1912408-92-4
- Formula:C55H88N8O11
- Molecular Weight:1037.33
IUPAC Name: 4-((S)-2-((S)-2-amino-3-methylbutanamido)propanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3
InChIKey: MTXKKTCVANNYBH-AXWSPWQFSA-N
SMILES: C[C@@H](C(N[C@H](C)[C@H](C1=CC=CC=C1)O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)=O)OC
Biological Activity: Val-Ala-PAB-MMAE is a Drug-Linker Conjugate for ADC, consisting of ADC linker (Val-Ala-PAB) and MMAE. MMAE is an effective inhibitor of tubulin.
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Val-Ala-PAB-MMAE | 99.72% | Val-Ala-PAB-MMAE is a Drug-Linker Conjugate for ADC, consisting of ADC linker (Val-Ala-PAB) and MMAE. MMAE is an effective inhibitor of tubulin. | ||||||||||||||||||||
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Val-Cit-PAB-MMAE (GMP) | Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization. | |||||||||||||||||||||
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Val-Cit-PAB-MMAF | Val-Cit-PAB-MMAF is a drug-Linker conjugate for ADC. Val-Cit-PAB-MMAF is composed of an ADC linker (peptide Val-Cit-PAB) and a potent microtubule polymerization inhibitor MMAF (HY-15579). | |||||||||||||||||||||
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Asn-Pro-Val-PABC-MMAE TFA | Asn-Pro-Val-PABC-MMAE TFA (compound 8) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs). | |||||||||||||||||||||
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MC-VA-PABC-MMAE | 99.93% | MC-VA-PABC-MMAE is a agent-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162). | ||||||||||||||||||||
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Ac-Lys-Val-Cit-PABC-MMAE | 99.94% | Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162). | ||||||||||||||||||||
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OH-Glu-Val-Cit-PAB-MMAE | 99.03% | OH-Glu-Val-Cit-PAB-MMAE consists a cleavable ADC linker (OH-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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(Aminooxy)acetamide-Val-Cit-PAB-MMAE | 96.87% | (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC. | ||||||||||||||||||||
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Boc-Val-Cit-PAB-MMAE | 99.72% | Boc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC, which is composed of a linker Boc-Val-Cit-PAB (HY141141) and a Microtubule inhibitor MMAE (HY-15162). Boc-Val-Cit-PAB-MMAE can be used for ADC synthesis. | ||||||||||||||||||||
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Aminocaproyl-Val-Cit-PABC-MMAE | 99.89% | Aminocaproyl-Val-Cit-PABC-MMAE is an Drug-linker conjugate for ADC. | ||||||||||||||||||||
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Ac-RKAA-PABC-MMAE | Ac-RKAA-PABC-MMAE is a Drug-Linker Conjugates for ADC. Ac-RKAA-PABC-MMAE consists of the ADC Cytotoxin MMAE (HY-15162) and a linker. Ac-RKAA-PABC-MMAE can be used for synthesis of ADCs. | |||||||||||||||||||||
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