1918142-34-3
Chemical Structure
CFTR corrector 4
- CAS No.: 1918142-34-3
- Formula:C29H27F2NO7
- Molecular Weight:539.52
IUPAC Name: 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-((2R,4R)-2-(3,4-dimethoxyphenyl)-7-methoxychroman-4-yl)cyclopropane-1-carboxamide
InChIKey: KDOQEEMQPHIANX-NFBKMPQASA-N
SMILES: O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)N[C@@H]4C[C@H](C5=CC=C(OC)C(OC)=C5)OC6=CC(OC)=CC=C46
Biological Activity: CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1].
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CFTR corrector 4 | 99.72% | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis. | ||||||||||||||||||||
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References
- [1]. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. [Content Brief]
