192374-14-4
192374-14-4
Chemical Structure
Radafaxine
Synonym(s): (S,S)-Hydroxybupropion; GW-353162A free base; BW-306U free base
- CAS No.: 192374-14-4
- Formula:C13H18ClNO2
- Molecular Weight:255.74
IUPAC Name: (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
InChIKey: RCOBKSKAZMVBHT-TVQRCGJNSA-N
SMILES: O[C@]1(C2=CC=CC(Cl)=C2)[C@H](C)NC(C)(C)CO1
Biological Activity: Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].
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Radafaxine | Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion. | |||||||||||||||||||||
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References
- [1]. Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57(6):640-6. [Content Brief]
- [2]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70. [Content Brief]
