192927-92-7
Chemical Structure
LY310762
- CAS No.: 192927-92-7
- Formula:C24H28ClFN2O2
- Molecular Weight:430.94
IUPAC Name: 1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-dimethylindolin-2-one hydrochloride
InChIKey: BOCLFQZPFYNVFD-UHFFFAOYSA-N
SMILES: O=C1N(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)C4=C(C=CC=C4)C1(C)C.[H]Cl
Biological Activity: LY310762 is a selective 5-HT1D receptor antagonist with a Ki value of 249 nM for the guinea pig receptor. LY310762 blocks presynaptic 5-HT1D autoreceptors and enhances potassium-stimulated [3H]5-HT outflow from guinea pig cortical slices. LY310762 abolishes the inhibitory effect of 5-CT (HY-135555)/L-694,247 (HY-101208) on sympathetic nerve-induced renal vasoconstriction mediated by prejunctional 5-HT1D receptors. LY310762 potentiates the increase in extracellular 5-HT concentration induced by Fluoxetine (HY-B0102). LY310762 is used in research related to depression and diabetic nephropathy[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
LY310762 | 98.89% | LY310762 is a selective 5-HT1D receptor antagonist with a Ki value of 249 nM for the guinea pig receptor. LY310762 blocks presynaptic 5-HT1D autoreceptors and enhances potassium-stimulated [3H]5-HT outflow from guinea pig cortical slices. LY310762 abolishes the inhibitory effect of 5-CT (HY-135555)/L-694,247 (HY-101208) on sympathetic nerve-induced renal vasoconstriction mediated by prejunctional 5-HT1D receptors. LY310762 potentiates the increase in extracellular 5-HT concentration induced by Fluoxetine (HY-B0102). LY310762 is used in research related to depression and diabetic nephropathy. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. European journal of pharmacology. 2004 Jun 16;493(1-3):85-93. [Content Brief]
- [2]. Fernández-González JF, et al. Renal Sympathetic Hyperactivity in Diabetes Is Modulated by 5-HT Receptor Activation via NO Pathway. International journal of molecular sciences. 2023 Jan 10;24(2):1378.
- [3]. García-Pedraza JÁ, et al. Vascular sympathetic neurotransmission and its serotonergic regulation are modified by chronic fluoxetine treatment. Journal of pharmacological sciences. 2021 Sep;147(1):48-57.
