193420-09-6
193420-09-6
Chemical Structure
Z-13752A
- CAS No.: 193420-09-6
- Formula:C22H22N2O3S2
- Molecular Weight:426.55
IUPAC Name: (S)-2-((S)-2-benzyl-3-mercaptopropanamido)-3-(4-(thiazol-2-yl)phenyl)propanoic acid
InChIKey: YPGILAVWVRBSAJ-MOPGFXCFSA-N
SMILES: SC[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=C(C3=NC=CS3)C=C2)C(O)=O)=O
Biological Activity: Z-13752A is a mercaptopropanoyl amino acid. Z-13752A inhibits NEP and ACE, with Ki values of 1.8 and 3.2 nM, respectively. Z-13752A decreases the arterial blood pressure and increases coronary blood flow. Z-13752A can be used in the research of coronary artery occlusion[1][2].
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Z-13752A | Z-13752A is a mercaptopropanoyl amino acid. Z-13752A inhibits NEP and ACE, with Ki values of 1.8 and 3.2 nM, respectively. Z-13752A decreases the arterial blood pressure and increases coronary blood flow. Z-13752A can be used in the research of coronary artery occlusion. | |||||||||||||||||||||
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References
- [1]. Robl J A, et al. Recent advances in the design and development of vasopeptidase inhibitors[J]. Expert Opinion on Therapeutic Patents, 1999, 9(12): 1665-1677.
- [2]. Venugopal J. Pharmacological modulation of the natriuretic peptide system[J]. Expert Opinion on Therapeutic Patents, 2003, 13(9): 1389-1409.
