1938081-40-3
Chemical Structure
DSPE-PEG2000-Azide ammonium
- CAS No.: 1938081-40-3
- Formula:(C2H4O)nC44H84N4O10P.NH4
- Molecular Weight:N/A
SMILES: CCCCCCCCCCCCCCCCCC(OCC(COP([O-])(OCCNC(OCCOCCN=[N+]=[N-])=O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O.[n].[NH4+]
Biological Activity: DSPE-PEG2000-Azide ammonium is an azide-functionalized phospholipid and lipid-polyethylene glycol conjugate. DSPE-PEG2000-Azide ammonium serves as a component of azide-functionalized liposome nanoparticles, which enables conjugation with DBCO-modified antibodies and proteins via strain-promoted alkyne-azide cycloaddition, and can also passively insert into exosome membranes through hydrophobic interactions, thereby achieving modular surface engineering via azide-alkyne click chemistry. DSPE-PEG-Azide ammonium binds to bovine milk exosomes with a KD of 347 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSPE-PEG2000-Azide ammonium | 99.9% | DSPE-PEG2000-Azide ammonium is an azide-functionalized phospholipid and lipid-polyethylene glycol conjugate. DSPE-PEG2000-Azide ammonium serves as a component of azide-functionalized liposome nanoparticles, which enables conjugation with DBCO-modified antibodies and proteins via strain-promoted alkyne-azide cycloaddition, and can also passively insert into exosome membranes through hydrophobic interactions, thereby achieving modular surface engineering via azide-alkyne click chemistry. DSPE-PEG-Azide ammonium binds to bovine milk exosomes with a KD of 347 μM. | ||||||||||||||||||||
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References
- [1]. Reyes-Esteves S, et al. Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage. Journal of controlled release : official journal of the Controlled Release Society. 2023 Apr;356:185-195. [Content Brief]
- [2]. Warren MR, et al. Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA. Biomaterials science. 2021 Jun 15;9(12):4260-4277. [Content Brief]
