1940118-04-6
Chemical Structure
SRI-31142
- CAS No.: 1940118-04-6
- Formula:C29H24N6
- Molecular Weight:456.54
IUPAC Name: 2-(7-methylimidazo[1,2-a]pyridin-6-yl)-N-(2-phenyl-2-(pyridin-4-yl)ethyl)quinazolin-4-amine
InChIKey: KMPKXUWMECJNNG-UHFFFAOYSA-N
SMILES: CC1=CC2=NC=CN2C=C1C3=NC(NCC(C4=CC=CC=C4)C5=CC=NC=C5)=C6C=CC=CC6=N3
Biological Activity: SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine[1].
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SRI-31142 | 99.89% | SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine. | ||||||||||||||||||||
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