19420-56-5
Chemical Structure
1-Oleoyl-sn-glycero-3-phosphocholine
Synonym(s): 18:1 Lyso PC
- CAS No.: 19420-56-5
- Formula:C26H52NO7P
- Molecular Weight:521.67
IUPAC Name: (R)-2-hydroxy-3-(oleoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: YAMUFBLWGFFICM-PTGWMXDISA-N
SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)O
Biological Activity: 1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation.1-Oleoyl-sn-glycero-3-phosphocholine exhibits reduced serum levels in mouse models of steatohepatitis, linked to hepatic Lpcat 1-4 up-regulation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Oleoyl-sn-glycero-3-phosphocholine | 99.58% | 1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation.1-Oleoyl-sn-glycero-3-phosphocholine exhibits reduced serum levels in mouse models of steatohepatitis, linked to hepatic Lpcat 1-4 up-regulation. | ||||||||||||||||||||
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1-Oleoyl-sn-glycero-3-phosphocholine (Standard) | ≥98% | 1-Oleoyl-sn-glycero-3-phosphocholine is an unsaturated 18:1 lysophosphatidylcholine formed in plasma by lecithin:cholesterol acyltransferase (LCAT). | ||||||||||||||||||||
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1-Oleoyl-sn-glycero-3-phosphocholine-d7 | 1-Oleoyl-sn-glycero-3-phosphocholine-d7 is deuterium labeled L-Alpha-Lysophosphatidylcholine,oleoyl. | |||||||||||||||||||||
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References
- [1]. Yasuda D, et al. Inverse agonism of lysophospholipids with cationic head groups at Gi-coupled receptor GPR82. Eur J Pharmacol. 2023;954:175893. [Content Brief]
- [2]. Tanaka N, et al. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology. 2012;56(1):118-129. [Content Brief]
