1946008-31-6
1946008-31-6
Chemical Structure
AChE/BuChE-IN-2
- CAS No.: 1946008-31-6
- Formula:C20H18N2O2
- Molecular Weight:318.37
IUPAC Name: 2-(benzo[d][1,3]dioxol-5-yl)-4-(pyrrolidin-1-yl)quinoline
InChIKey: BJQZRZYHRTZRQE-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(OCO3)C3=C2)=NC4=CC=CC=C4C(N5CCCC5)=C1
Biological Activity: AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB[1].
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AChE/BuChE-IN-2 | AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC50 of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB. | |||||||||||||||||||||
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