195209-04-2
195209-04-2
Chemical Structure
ACPT-II
- CAS No.: 195209-04-2
- Formula:C8H11NO6
- Molecular Weight:217.18
IUPAC Name: (1R,2S,4r)-4-aminocyclopentane-1,2,4-tricarboxylic acid
InChIKey: FERIKTBTNCSGJS-OCDMWJSJSA-N
SMILES: OC([C@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)N)=O
Biological Activity: ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].
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ACPT-II | ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects. | |||||||||||||||||||||
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References
- [1]. Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29. [Content Brief]
- [2]. Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94. [Content Brief]
- [3]. Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26(1):99-113. [Content Brief]
- [4]. Chapman AG, et al. Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424(2):107-13. [Content Brief]
- [5]. Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57(3):227-34. [Content Brief]
