1957278-93-1
1957278-93-1
Chemical Structure
Aldumastat
Synonym(s): GLPG1972; S201086
- CAS No.: 1957278-93-1
- Formula:C20H24F2N4O3
- Molecular Weight:406.43
IUPAC Name: (S)-5-cyclopropyl-5-(3-((S)-4-(3,5-difluorophenyl)-3-methylpiperazin-1-yl)-3-oxopropyl)imidazolidine-2,4-dione
InChIKey: CMLVKUWQFZQPPS-YUNKPMOVSA-N
SMILES: O=C(N(CCN1C2=CC(F)=CC(F)=C2)C[C@@H]1C)CC[C@](NC3=O)(C4CC4)C(N3)=O
Biological Activity: Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aldumastat | 99.36% | Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research. | ||||||||||||||||||||
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