1962928-25-1
1962928-25-1
Chemical Structure
MRT 68601 hydrochloride
- CAS No.: 1962928-25-1
- Formula:C25H35ClN6O2
- Molecular Weight:487.04
IUPAC Name: N-(3-((5-cyclopropyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide hydrochloride
InChIKey: BOBHGYDEKISHIZ-UHFFFAOYSA-N
SMILES: O=C(C1CCC1)NCCCNC2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2C5CC5.Cl
Biological Activity: MRT 68601 hydrochloride is a TBK1 inhibitor with an IC50 value of 6 nM. MRT 68601 hydrochloride inhibits autophagosome formation in lung cancer cells[1][2].
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MRT 68601 hydrochloride | MRT 68601 hydrochloride is a TBK1 inhibitor with an IC50 value of 6 nM. MRT 68601 hydrochloride inhibits autophagosome formation in lung cancer cells. | |||||||||||||||||||||
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References
- [1]. Newman AC, et al. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS One. 2012;7(11):e50672. [Content Brief]
- [2]. McIver EG, et al. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73. [Content Brief]
