196517-43-8
Chemical Structure
ER-38925
- CAS No.: 196517-43-8
- Formula:C21H17NO3
- Molecular Weight:331.37
IUPAC Name: 4-(5-(4,7-dimethylbenzofuran-2-yl)-1H-pyrrol-2-yl)benzoic acid
InChIKey: LSZNZLWBRQAWNH-UHFFFAOYSA-N
SMILES: O=C(O)C=1C=CC(=CC1)C2=CC=C(N2)C=3OC4=C(C3)C(=CC=C4C)C
Biological Activity: ER-38925 is a retinoid agonist with selevtivity to retinoic acid receptor subtype α (RAR-α). ER-38925 prolongs the lifespan of the recipient mice dose-dependently. ER-38925 potently inhibits alloantigenstimulated donor T lymphocyte prolifertion in vitro. ER-38925 can prevent the development of antiallogeneic cytotoxic T lymphocyte response in mice. ER-38925 inhibits serum anti-DNA autoantibody production in mouse model of human chronic GVHD[1].
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ER-38925 | ER-38925 is a retinoid agonist with selevtivity to retinoic acid receptor subtype α (RAR-α). ER-38925 prolongs the lifespan of the recipient mice dose-dependently. ER-38925 potently inhibits alloantigenstimulated donor T lymphocyte prolifertion in vitro. ER-38925 can prevent the development of antiallogeneic cytotoxic T lymphocyte response in mice. ER-38925 inhibits serum anti-DNA autoantibody production in mouse model of human chronic GVHD. | |||||||||||||||||||||
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