1966181-14-5
Chemical Structure
Fonagepant
Synonym(s): FE 205030
- CAS No.: 1966181-14-5
- Formula:C66H88N16O16S2
- Molecular Weight:1425.63
InChIKey: NDNYKUCHDRUVEM-YKOQRXGISA-N
SMILES: O=C1[C@@]2([H])N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](N1)CC3=CC=CC=C3)=O)C(N[C@H](C(N)=O)CC4=CN=CC=C4)=O)NC([C@@H](NC([C@@H](C(C)C)NC(C5=NC=CO5)=O)=O)CC6=C(C=CC=C6)C(N)=O)=O)=O)CCCNC(C)C)=O)CC(O)=O)=O)C(C)C)=O)=O)CCC2
Biological Activity: Fonagepant (FE 205030) is a calcitonin gene-related peptide (CGRP) receptor antagonist with an IC50 of 0.2 nM. Fonagepant selectively blocks CGRP receptor activity, inhibits CGRP-induced vasodilation, attenuates capsaicin-induced increase in skin blood flow, and blocks CGRP-induced vasodilation in isolated human mesenteric resistance arteries. Fonagepant can be used in studies related to acute migraine attacks[1].
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Fonagepant | Fonagepant (FE 205030) is a calcitonin gene-related peptide (CGRP) receptor antagonist with an IC50 of 0.2 nM. Fonagepant selectively blocks CGRP receptor activity, inhibits CGRP-induced vasodilation, attenuates capsaicin-induced increase in skin blood flow, and blocks CGRP-induced vasodilation in isolated human mesenteric resistance arteries. Fonagepant can be used in studies related to acute migraine attacks. | |||||||||||||||||||||
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