1974271-78-7
Chemical Structure
Sulfo-QSY21-NHS
- CAS No.: 1974271-78-7
- Formula:C45H39ClN4O13S3
- Molecular Weight:975.46
InChIKey: GXCGJHGIWCKXTJ-UHFFFAOYSA-N
SMILES: O=C(C1CCN(S(=O)(C2=C(C3=C4C=CC(N5C6=CC=C(S(=O)(O)=O)C=C6CC5)=CC4=[O+]C7=C3C=CC(N8C9=CC=C(S(=O)(O)=O)C=C9CC8)=C7)C=CC=C2)=O)CC1)ON%10C(CCC%10=O)=O.[Cl-]
Biological Activity: Sulfo-QSY21-NHS is an N-hydroxysuccinimide ester derivative fluorescent quencher that reduces the fluorescence intensity of paired fluorophores via proximity effect and relieves quenching after linker extension induced by mechanical force. Sulfo-QSY21-NHS can label streptavidin through NHS ester bioconjugation and be integrated into fluorescence-based molecular tension sensors to map the mechanical forces of cell surface receptors. Sulfo-QSY21-NHS also serves as a quencher for cysteine cathepsin-targeted quenched fluorescent substrate probes, and is widely used in studies related to breast cancer, colorectal cancer and lung adenocarcinoma[1][2].
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Sulfo-QSY21-NHS | Sulfo-QSY21-NHS is an N-hydroxysuccinimide ester derivative fluorescent quencher that reduces the fluorescence intensity of paired fluorophores via proximity effect and relieves quenching after linker extension induced by mechanical force. Sulfo-QSY21-NHS can label streptavidin through NHS ester bioconjugation and be integrated into fluorescence-based molecular tension sensors to map the mechanical forces of cell surface receptors. Sulfo-QSY21-NHS also serves as a quencher for cysteine cathepsin-targeted quenched fluorescent substrate probes, and is widely used in studies related to breast cancer, colorectal cancer and lung adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Stabley DR, et al. Visualizing mechanical tension across membrane receptors with a fluorescent sensor. Nature methods. 2011 Oct 30;9(1):64-7. [Content Brief]
- [2]. Ofori LO, et al. Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery. ACS chemical biology. 2015 Sep 18;10(9):1977-88. [Content Brief]
