197508-62-6
Chemical Structure
(±)14,15-Epoxyeicosatrienoic acid
Synonym(s): (±)14(15)-EET
- CAS No.: 197508-62-6
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: 1-iodo-4-(methyl-d3)benzene-2,3,5,6-d4
InChIKey: JBSCUHKPLGKXKH-ILYOTBPNSA-N
SMILES: OC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O
Biological Activity: (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth[1][2].
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(±)14,15-Epoxyeicosatrienoic acid | 99.9% | (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth. | ||||||||||||||||||||
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References
- [1]. Mitra R, et al. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). J Biol Chem. 2011 May 20;286(20):17543-59. [Content Brief]
- [2]. Zhang DX, et al. Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites. Endocrinology. 2004 Oct;145(10):4532-9. [Content Brief]
