1977-10-2
1977-10-2
Chemical Structure
Loxapine
- CAS No.: 1977-10-2
- Formula:C18H18ClN3O
- Molecular Weight:327.81
IUPAC Name: 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
InChIKey: XJGVXQDUIWGIRW-UHFFFAOYSA-N
SMILES: CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1
Biological Activity: Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][4].
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Loxapine | 99.93% | Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent. | ||||||||||||||||||||
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Loxapine (Standard) | ≥98% | Loxapine (Standard) is the analytical standard of Loxapine. This product is intended for research and analytical applications. Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent. | ||||||||||||||||||||
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References
- [1]. Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. [Content Brief]
- [4]. Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4. [Content Brief]
