1977493-48-3
1977493-48-3
Chemical Structure
m-PEG12-amine
- CAS No.: 1977493-48-3
- Formula:C25H53NO12
- Molecular Weight:559.69
IUPAC Name: 2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-amine
InChIKey: MSKSQCLPULZWNO-UHFFFAOYSA-N
SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Biological Activity: m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
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m-PEG12-amine | 99.71% | m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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Amino-PEG11-amine | 95.0% | Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer. | ||||||||||||||||||||
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Amino-PEG12-amine | 99.92% | Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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Propargyl-PEG12-amine | Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG12-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Propargyl-PEG11-methane | Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Amino-PEG12-alcohol | 99.78% | Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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m-PEG12-azide | 98.6% | m-PEG12-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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m-PEG12-OH | 100.00% | m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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m-PEG12-Thiol | 95.0% | m-PEG12-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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m-PEG12-Br | m-PEG12-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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m-PEG11-Amine | 96.0% | m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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References
- [1]. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. [Content Brief]
- [2]. Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.
