1977557-69-9
Chemical Structure
(rel)-Salcolin A
- CAS No.: 1977557-69-9
- Formula:C27H26O11
- Molecular Weight:526.49
InChIKey: WXNJNHFYIWEHIL-AOYPEHQESA-N
SMILES: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(OC)=C(C(OC)=C3)O[C@H](CO)[C@@H](C4=CC(OC)=C(C=C4)O)O)=C1
Biological Activity: (rel)-Salcolin A is a flavonoid lignan compound with anticancer, anti-inflammatory, and neuroprotective activities. (rel)-Salcolin A has IC50 values ??of 66.69 μM and 56.12 μM against anaplastic thyroid carcinoma cells (HTH83) and papillary thyroid carcinoma cells (TPC1), respectively. (rel)-Salcolin A also inhibits LPS-induced NO production with an IC50 of 14.65 μM. (rel)-Salcolin A exerts its effects by inducing necroptosis in thyroid cancer cells, inhibiting the production of the inflammatory factor NO, and protecting against glutamate-induced neuronal cell damage, with a neuroprotective E50 of 47.44 μM. (rel)-Salcolin A can be used in research related to thyroid cancer, anti-inflammation, and neuroprotection. (rel)-Salcolin A can be naturally extracted from the leaves of Casearia arborea and the stems of Zea mays (corn)[1][2].
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(rel)-Salcolin A | (rel)-Salcolin A is a flavonoid lignan compound with anticancer, anti-inflammatory, and neuroprotective activities. (rel)-Salcolin A has IC50 values ??of 66.69 μM and 56.12 μM against anaplastic thyroid carcinoma cells (HTH83) and papillary thyroid carcinoma cells (TPC1), respectively. (rel)-Salcolin A also inhibits LPS-induced NO production with an IC50 of 14.65 μM. (rel)-Salcolin A exerts its effects by inducing necroptosis in thyroid cancer cells, inhibiting the production of the inflammatory factor NO, and protecting against glutamate-induced neuronal cell damage, with a neuroprotective E50 of 47.44 μM. (rel)-Salcolin A can be used in research related to thyroid cancer, anti-inflammation, and neuroprotection. (rel)-Salcolin A can be naturally extracted from the leaves of Casearia arborea and the stems of Zea mays (corn). | |||||||||||||||||||||
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References
- [1]. Jung YJ, et al. Lignan and flavonoids from the stems of Zea mays and their anti-inflammatory and neuroprotective activities. Arch Pharm Res. 2015 Feb;38(2):178-85. [Content Brief]
- [2]. Santos AL, et al. Exploring the Antiproliferative Activity of Flavolignans From the Leaves of Casearia arborea (Salicaceae). Chem Biodivers. 2025 Dec;22(12):e01489. [Content Brief]
