1983924-33-9
Chemical Structure
Anticancer agent 253
- CAS No.: 1983924-33-9
- Formula:C29H23F3N4O
- Molecular Weight:500.51
IUPAC Name: 1-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-3,5-bis((E)-2-fluorobenzylidene)piperidin-4-one
InChIKey: GRSQHVJEBDBQLN-RNIAWFEPSA-N
SMILES: O=C(/C(CN(C/1)CC2=CN(N=N2)CC3=CC=C(C=C3)F)=C/C4=C(C=CC=C4)F)C1=C\C5=C(C=CC=C5)F
Biological Activity: Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC50s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells). Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer[1].
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Anticancer agent 253 | Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC50s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells). Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer. | |||||||||||||||||||||
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