1993-03-9
Chemical Structure
2-Fluorophenylboronic acid
- CAS No.: 1993-03-9
- Formula:C6H6BFO2
- Molecular Weight:139.92
IUPAC Name: (2-fluorophenyl)boronic acid
InChIKey: QCSLIRFWJPOENV-UHFFFAOYSA-N
SMILES: FC1=CC=CC=C1B(O)O
Biological Activity: 2-Fluorophenylboronic acid is an organic synthesis intermediate belonging to the fluorinated arylboronic acid class. The electron-withdrawing fluorine substituent in 2-Fluorophenylboronic acid reduces its pKa, thereby enhancing boronate bond formation with diols. 2-Fluorophenylboronic acid serves as a key synthetic intermediate for inhibitors of Plasmodium phosphatidylinositol 4-kinase IIIβ (PI4K). 2-Fluorophenylboronic acid can also be used to functionalize linear polyglycerols for constructing dual dynamic covalent cross-linked hydrogels that support 3D tumor spheroid culture of various cancer cells. 2-Fluorophenylboronic acid is applicable to research related to malaria and tumors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Fluorophenylboronic acid | 99.99% | 2-Fluorophenylboronic acid is an organic synthesis intermediate belonging to the fluorinated arylboronic acid class. The electron-withdrawing fluorine substituent in 2-Fluorophenylboronic acid reduces its pKa, thereby enhancing boronate bond formation with diols. 2-Fluorophenylboronic acid serves as a key synthetic intermediate for inhibitors of Plasmodium phosphatidylinositol 4-kinase IIIβ (PI4K). 2-Fluorophenylboronic acid can also be used to functionalize linear polyglycerols for constructing dual dynamic covalent cross-linked hydrogels that support 3D tumor spheroid culture of various cancer cells. 2-Fluorophenylboronic acid is applicable to research related to malaria and tumors. | ||||||||||||||||||||
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References
- [1]. Feng J, et al. Dual-Dynamic Covalently Cross-Linked Polyglycerol Hydrogels for Tumor Spheroid Culture. Biomacromolecules. 2025 Jun 09;26(6):3331-3343. [Content Brief]
- [2]. Dziwornu GA, et al. Novel Inhibitors of Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and Efficacy in a Humanized Mouse Malaria Infection Model. Journal of medicinal chemistry. 2025 Aug 28;68(16):17736-17751. [Content Brief]
