199329-53-8
Chemical Structure
L-Cystine disodium monohydrate
- CAS No.: 199329-53-8
- Formula:C6H12N2Na2O5S2
- Molecular Weight:302.28
InChIKey: TVPDKJXPEMKMDM-BLZBDRIDSA-L
SMILES: N[C@@H](CSSC[C@H](N)C(O[Na])=O)C(O[Na])=O.O
Biological Activity: L-Cystine disodium monohydrate is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine disodium monohydrate elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine disodium monohydrate reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine disodium monohydrate combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine disodium monohydrate is promising for research of cystinuria and kidney stones[1][2][3][4][5][6].
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L-Cystine disodium monohydrate | L-Cystine disodium monohydrate is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine disodium monohydrate elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine disodium monohydrate reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine disodium monohydrate combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine disodium monohydrate is promising for research of cystinuria and kidney stones. | |||||||||||||||||||||
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References
- [1]. Abdullah M, et al. Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc- Inhibitors[J]. Biomol Ther (Seoul). 2022 Mar 1;30(2):184-190. [Content Brief]
- [2]. Kurihara S, et al. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine[J]. J Vet Med Sci. 2007 Dec;69(12):1263-70. [Content Brief]
- [3]. Dominique Bazin,et al. Cystinuria and cystinosis are usually related to L-cystine: is this really the case for cystinosis? A physicochemical investigation at micrometre and nanometre scale. Comptes Rendus. Chimie, Volume 25 (2022) no. S1, pp. 489-502.
- [4]. Greth WE, et al. Cellular accumulation of L-cystine in rat kidney cortex in vivo[J]. J Clin Invest. 1973 Feb;52(2):454-62. [Content Brief]
- [5]. Ohtsu I, et al. Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. PLoS One. 2015 Apr 2;10(3):e0120619. [Content Brief]
- [6]. Dai W, et al. Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture[J]. Cells. 2023 Jan 12;12(2):291. [Content Brief]
