1997321-76-2
1997321-76-2
Chemical Structure
PBRM1/SMARCA2,4-ligand-1
- CAS No.: 1997321-76-2
- Formula:C16H13N3O
- Molecular Weight:263.29
InChIKey: SDAWPVIWTVUTCC-UHFFFAOYSA-N
SMILES: NC1=C(C=C(N=N1)C2=C(C=CC=C2)O)C3=CC=CC=C3
Biological Activity: PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410)[1][2].
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PBRM1/SMARCA2,4-ligand-1 | PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410). | |||||||||||||||||||||
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References
- [1]. Taylor, A. M., et al., (2022). GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. Journal of medicinal chemistry, 65(16), 11177–11186. [Content Brief]
- [2]. Tongchen He, et al. Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer. bioRxiv [Preprint]. 2024 Mar 2:2024.02.29.582768. [Content Brief]
