2012598-78-4
2012598-78-4
Chemical Structure
(Rac)-5-Hydroxymethyl tolterodine-d5
Synonym(s): (Rac)-Desfesoterodine-d5;(Rac)-PNU-200577-d5
- CAS No.: 2012598-78-4
- Formula:C22H26D5NO2
- Molecular Weight:346.52
IUPAC Name: (S)-4-((2-hydroxyethyl)sulfonamido)-N-(6-(2-methylmorpholino)pyridin-2-yl)-2-(6-azaspiro[2.5]octan-6-yl)benzamide
InChIKey: DUXZAXCGJSBGDW-CFEWMVNUSA-N
SMILES: CC(C)N(C(C)C)CCC(C1=CC(CO)=CC=C1O)C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]
Biological Activity: (Rac)-5-hydroxymethyl Tolterodine-d5 ((Rac)-Desfesoterodine-d5; (Rac)-PNU-200577-d5) is deuterium-labeled (Rac)-5-Hydroxymethyl Tolterodine (HY-76570)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Rac)-5-Hydroxymethyl tolterodine-d5 | (Rac)-5-hydroxymethyl Tolterodine-d5 ((Rac)-Desfesoterodine-d5; (Rac)-PNU-200577-d5) is deuterium-labeled (Rac)-5-Hydroxymethyl Tolterodine (HY-76570). | |||||||||||||||||||||
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(Rac)-5-Hydroxymethyl Tolterodine-d14 | (Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research. | |||||||||||||||||||||
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5-Hydroxymethyl Tolterodine-d14 formate | 5-Hydroxymethyl Tolterodine-d14 (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research. | |||||||||||||||||||||
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(Rac)-5-Hydroxymethyl Tolterodine | 98.95% | (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research. | ||||||||||||||||||||
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PNU-200579 | PNU-200579 is a metabolite of Tolterodine (HY-A0024) in dog urine. | |||||||||||||||||||||
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Fesoterodine | 99.61% | Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB). | ||||||||||||||||||||
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5-Hydroxymethyl tolterodine formate | 5-Hydroxymethyl tolterodine (formate) (PNU-200577 (formic)) is an active metabolite of the muscarinic acetylcholine receptor antagonists Tolterodine (HY-A0024) and Fesoterodine (HY-70053). 5-Hydroxymethyl tolterodine (formate) is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases. | |||||||||||||||||||||
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Desfesoterodine (Standard) | ≥98% | Desfesoterodine (Standard) is the analytical standard of Desfesoterodine. This product is intended for research and analytical applications. Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats. | ||||||||||||||||||||
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(Rac)-5-Hydroxymethyl Tolterodine hydrochloride | (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research. | |||||||||||||||||||||
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Tolterodine impurity 1 (Standard) | ≥98% | (S)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol (Standard) is the analytical standard of (S)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Tolterodine | 98.61% | Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder. | ||||||||||||||||||||
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Fesoterodine impurity 1 (Standard) | ≥98% | 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(methoxymethyl)phenol (Standard) is the analytical standard of 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(methoxymethyl)phenol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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(S)-Tolterodine | (S)-Tolterodine is a muscarinic acetylcholine receptor (mAChR) inhibitor, with an IC50 of 588 nM. | |||||||||||||||||||||
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(Rac)-5-Carboxy tolterodine | (Rac)-5-Carboxy tolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist Tolterodine (HY-A0024). | |||||||||||||||||||||
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