201605-51-8
Chemical Structure
Itriglumide
Synonym(s): CR 2945
- CAS No.: 201605-51-8
- Formula:C33H38N2O4
- Molecular Weight:526.67
IUPAC Name: (R)-5-((2,4-dimethyl-6-(8-azaspiro[4.5]decane-8-carbonyl)phenyl)amino)-3-(naphthalen-1-yl)-5-oxopentanoic acid
InChIKey: MFOOVZCXWVAWOV-RUZDIDTESA-N
SMILES: O=C(C1=C(C(C)=CC(C)=C1)NC(C[C@@H](C2=CC=CC3=CC=CC=C23)CC(O)=O)=O)N4CCC5(CCCC5)CC4
Biological Activity: Itriglumide (CR 2945) is an anthranilic acid derivative. Itriglumide is a potent and selective CCKB receptor antagonist, with an IC50 of 2.3 nM. Itriglumide antagonizes the response to gastrin in a dose-dependent manner with an IC50 of 5.9 nM. Itriglumide shows antisecretory and antiulcer activity[1].
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Itriglumide | Itriglumide (CR 2945) is an anthranilic acid derivative. Itriglumide is a potent and selective CCKB receptor antagonist, with an IC50 of 2.3 nM. Itriglumide antagonizes the response to gastrin in a dose-dependent manner with an IC50 of 5.9 nM. Itriglumide shows antisecretory and antiulcer activity. | |||||||||||||||||||||
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