201849-55-0
201849-55-0
Chemical Structure
Boc-Gln-Ala-Arg-AMC hydrochloride
- CAS No.: 201849-55-0
- Formula:C29H43ClN8O8
- Molecular Weight:667.15
IUPAC Name: tert-butyl ((S)-5-amino-1-(((S)-1-(((S)-5-guanidino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-1,5-dioxopentan-2-yl)carbamate hydrochloride
InChIKey: PJANUSPBJOFUEZ-BOKRKPFNSA-N
SMILES: CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCC(N)=O)NC(OC(C)(C)C)=O)=O)=O)=O)C=C1O2)=CC2=O.Cl
Biological Activity: Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2[1][2].
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Boc-Gln-Ala-Arg-AMC hydrochloride | Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2. | |||||||||||||||||||||
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References
- [1]. Mosztbacher D, et al. Measuring digestive protease activation in the mouse pancreas. Pancreatology. 2020 Mar;20(2):288-292. [Content Brief]
- [2]. Ko CJ, et al. Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. Oncogene. 2020 Sep;39(37):5950-5963. [Content Brief]
