201939-40-4
201939-40-4
Chemical Structure
PTAC oxalate
- CAS No.: 201939-40-4
- Formula:C14H21N3O4S2
- Molecular Weight:359.46
IUPAC Name: 3-((1R,5R,6R)-1-azabicyclo[3.2.1]octan-6-yl)-4-(propylthio)-1,2,5-thiadiazole oxalate
InChIKey: LXXQOVMTAFXOKQ-IYPAPVHQSA-N
SMILES: CCCSC1=NSN=C1[C@@H]2[C@@H]3C[N@@](CCC3)C2.OC(C(O)=O)=O
Biological Activity: PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].
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PTAC oxalate | PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects. | |||||||||||||||||||||
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References
- [1]. F P Bymaster, et al. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19. [Content Brief]
- [2]. (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr;124(4):1330-1338. [Content Brief]
