2026635-66-3
Chemical Structure
GNE 5729
- CAS No.: 2026635-66-3
- Formula:C17H10Cl2F3N5O
- Molecular Weight:428.20
IUPAC Name: (1R,2R)-2-(7-chloro-2-((5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile
InChIKey: GPMGDUIAVSFGGH-WCBMZHEXSA-N
SMILES: ClC1=C([C@H]2[C@H](C#N)C2)N3C(C=C1)=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC3=O
Biological Activity: GNE 5729 is an orally active, blood-brain barrier-penetrant positive allosteric modulator of NMDARs containing the GluN2A subunit. GNE 5729 enhances NMDAR responses through allosteric modulation, exhibits selectivity over other NMDAR subtypes and AMPARs, and can be used for research on depression[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNE 5729 | 99.05% | GNE 5729 is an orally active, blood-brain barrier-penetrant positive allosteric modulator of NMDARs containing the GluN2A subunit. GNE 5729 enhances NMDAR responses through allosteric modulation, exhibits selectivity over other NMDAR subtypes and AMPARs, and can be used for research on depression. | ||||||||||||||||||||
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References
- [1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved Profile. ACS medicinal chemistry letters. 2017 Jan 12;8(1):84-89. [Content Brief]
- [2]. Wang G, et al. GluN2A: A Promising Target for Developing Novel Antidepressants. The international journal of neuropsychopharmacology. 2024 Sep 01;27(9):pyae037.
- [3]. Hanson JE, et al. GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models. Cell reports. 2020 Jan 14;30(2):381-396.e4.
- [4]. Fu H, et al. Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors. Journal of medicinal chemistry. 2019 Jan 24;62(2):403-419.
