202796-42-7
202796-42-7
Chemical Structure
trans-J-113863
- CAS No.: 202796-42-7
- Formula:C30H37Cl2IN2O2
- Molecular Weight:655.44
IUPAC Name: (1r,4r)-1-(((E)-cyclooct-1-en-1-yl)methyl)-4-(2,7-dichloro-9H-xanthene-9-carboxamido)-1-ethylpiperidin-1-ium iodide
InChIKey: FOAFBMYSXIGAOX-MUMZCOSOSA-N
SMILES: CC[N@+]1(C/C2=C/CCCCCC2)CC[C@H](NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1.[I-]
Biological Activity: trans-J-113863 is a potent chemokine CCR1 and CCR3 receptor antagonist, and inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM,respectively[1][2].
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trans-J-113863 | trans-J-113863 is a potent chemokine CCR1 and CCR3 receptor antagonist, and inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM,respectively. | |||||||||||||||||||||
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References
- [1]. Sabroe I, et al. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 2000;275(34):25985-25992. [Content Brief]
- [2]. de Mendonça FL, et al. Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J Biol Chem. 2005;280(6):4808-4816. [Content Brief]
