2028300-31-2
Chemical Structure
20S Proteasome-IN-2
- CAS No.: 2028300-31-2
- Formula:C30H44N4O8S
- Molecular Weight:620.76
IUPAC Name: (S)-N1-((S)-1-(((S)-1-(furan-2-yl)-4-methyl-1-oxopentan-2-yl)amino)-3-methoxy-1-oxopropan-2-yl)-2-((4-methylphenyl)sulfonamido)-N4-neopentylsuccinamide
InChIKey: SRRHMJFNPOAJHK-HJOGWXRNSA-N
SMILES: O=C(N[C@@H](COC)C(N[C@@H](CC(C)C)C(C1=CC=CO1)=O)=O)[C@@H](NS(=O)(C2=CC=C(C)C=C2)=O)CC(NCC(C)(C)C)=O
Biological Activity: 20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M[1].
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20S Proteasome-IN-2 | 20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M. | |||||||||||||||||||||
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