202914-18-9
Chemical Structure
Indantadol hydrochloride
Synonym(s): CHF-3381
- CAS No.: 202914-18-9
- Formula:C11H15ClN2O
- Molecular Weight:226.70
IUPAC Name: 2-((2,3-dihydro-1H-inden-2-yl)amino)acetamide hydrochloride
InChIKey: JPNNIRXUJSPGRM-UHFFFAOYSA-N
SMILES: O=C(CNC1CC2=C(C1)C=CC=C2)N.Cl
Biological Activity: Indantadol hydrochloride (CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol hydrochloride blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol hydrochloride completely inhibits dopamine release caused by NMDA. Indantadol hydrochloride protects neurons, with an ED₅₀ of 35 μM. Indantadol hydrochloride has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].
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Indantadol hydrochloride | Indantadol hydrochloride (CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol hydrochloride blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol hydrochloride completely inhibits dopamine release caused by NMDA. Indantadol hydrochloride protects neurons, with an ED₅₀ of 35 μM. Indantadol hydrochloride has anticonvulsant and anti-high pain hypersensitivity activities. | |||||||||||||||||||||
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References
- [1]. Silvia Zucchini, et al. Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. Neuroreport. 2022, 13, 6. [Content Brief]
- [2]. Mattia C, Coluzzi F. Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. IDrugs. 2007 Sep;10(9):636-44. [Content Brief]
- [3]. Gandolfi O, et al. Anticonvulsant preclinical profile of CHF 3381: dopaminergic and glutamatergic mechanisms. Pharmacol Biochem Behav. 2001 Sep;70(1):157-66. [Content Brief]
