2034-72-2
2034-72-2
Chemical Structure
Stigmasta-3,5-dien-7-one
- CAS No.: 2034-72-2
- Formula:C29H46O
- Molecular Weight:410.67
InChIKey: LCFUUGFUQQAYMY-CJAQKTMASA-N
SMILES: O=C1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CC[C@@H](CC)C(C)C)(CC[C@]2([H])[C@@]4(C(C=CCC4)=C1)C)C
Biological Activity: Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE2, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Stigmasta-3,5-dien-7-one | 99.84% | Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE2, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases. | ||||||||||||||||||||
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Delta3,5-cholestadien-7-one | 95% | Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons. | ||||||||||||||||||||
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Stigmast-5-ene-3,7-dione | Stigmast-5-ene-3,7-dione (Compound 10) is a compound isolated from the roots, leaves and twigs of Penianthus longifolius. | |||||||||||||||||||||
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Stigmast-4-en-3,6-dione | Stigmast-4-en-3,6-dione is an anti-inflammatory and anti-allergic agent which can be extracted from Hibiscus cannabinus and Piper betle. | |||||||||||||||||||||
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β-Sitostenone | 95.0% | β-Sitostenone (Δ4-Sitosterol-3-one; β-Rosasterol oxide) is a sterol isolated from Cleistanthus eberhardtii. β-Sitostenone inhibits tyrosinase (tyrosinase) and cyclooxygenase (COX-1 and COX-2). β-Sitostenone has potential anti-melanogenic, anticancer, and anti-inflammatory activities. β-Sitostenone can be used in research on inflammation, cancer, and cosmetics. | ||||||||||||||||||||
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(3β,24S)-3-Hydroxystigmast-5-en-7-one | (3β,24S)-3-Hydroxystigmast-5-en-7-one (Compound 31) is a compound that can be isolated from Lindera akoensis . (3β,24S)-3-Hydroxystigmast-5-en-7-one has anti-inflammatory activity. | |||||||||||||||||||||
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Sitosterone | Sitosterone is a steroid that can be isolated from stem bark of syzygium aqueum. Sitosterone shows cytotoxicity. | |||||||||||||||||||||
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7-Ketositosterol | 99.9% | 7-Ketositosterol is an orally active inducer of apoptosis and ferroptosis. 7-Ketositosterol inhibits the phosphorylation of ERK1/2 and NF-κB, promotes the opening of the mitochondrial/apoptotic pathway, and induces ferroptosis in macrophages by increasing the levels of malondialdehyde, Fe2+ and ROS. 7-Ketositosterol upregulates the expression of gut microbiota-dependent PDLIM3, activates the p38MAPK/NF-κB signaling pathway, alters the composition of gut microbiota, increases the abundance of pathogenic bacteria, and exacerbates colitis in mice. 7-Ketositosterol can be used in studies related to breast cancer, liver cancer, and colitis. | ||||||||||||||||||||
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Cholesta-3,5-diene | 99.54% | Cholesta-3,5-diene is an inflammatory modulator that targets immune cells such as neutrophils and accelerates wound healing by promoting neutrophil chemotaxis and fibroblast migration. Cholesta-3,5-diene enhances immune cell recruitment and extracellular matrix deposition by activating chemokine receptor-mediated signaling pathways such as PI3K/Akt. Cholesta-3,5-diene can be applied topically to wound repair and has potential therapeutic value in chronic ulcers or skin lesions. | ||||||||||||||||||||
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Stigmasta-3,5-diene | Stigmasta-3,5-diene is a biochemical reagent. | |||||||||||||||||||||
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(3β)-3-Hydroxyergost-5-en-7-one | (3β)-3-Hydroxyergost-5-en-7-one is a natural steroid. | |||||||||||||||||||||
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References
- [1]. Park SJ, et al. Anti-inflammatory Steroid from Phragmitis rhizoma Modulates LPS-Mediated Signaling Through Inhibition of NF-κB Pathway. Inflammation. 2016;39(2):727-734. [Content Brief]
- [2]. Baldé AM, et al. Steroids from Harrisonia abyssinica. Planta Med. 2000;66(1):67-69. [Content Brief]
- [3]. Szakiel A, et al. Triterpenoid content of berries and leaves of bilberry Vaccinium myrtillus from Finland and Poland. J Agric Food Chem. 2012;60(48):11839-11849. [Content Brief]
